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The Best Nootropics for Anxiety and Depression

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Can nootropics help you manage feelings of anxiety and depression?

You’ve landed on this blogpost which probably means that like many others, you turned Google and asked “can nootropics help with anxiety and depression”. Well, you’ve come to the right place. In this article we’ll explore how nootropics work, in what ways could it help reduce anxiety and manage low moods and depresssive states and of course, the different types of nootropics (natural and synthetic) recommended for this specific purpose.

In today’s fast-paced world, excitement and possibilities abound, but it can also feel overwhelming. Anxiety and depression can negatively impact both our mental and physical health. Did you know that feeling depressed can hurt our cognitive performance too? Emotional distress and a reduced quality of life can worsen our mental state, potentially leading to issues like panic attacks and substance abuse. On the physical side, anxiety and depression can disrupt sleep, cause chronic fatigue, loss of appetite, weaken our immune system, and even result in chronic pain like headaches and digestive problems.

Fortunately, nootropics offers a beacon of hope. It can help give you the energy to face each day knowing you’re in control of your mental health and emotional wellbeing. 

But first, how do nootropics work? 

Nootropics, often called “smart drugs,” help manage anxiety and depression by boosting the brain’s natural chemistry. They enhance the production of key neurotransmitters like serotonin, dopamine, and GABA, which are essential for keeping our mood stable and emotions in check. Some nootropics make our brains more adaptable, helping us handle stress and emotional ups and downs better. Others have antioxidant and anti-inflammatory benefits, protecting our brain cells and reducing inflammation linked to depression and anxiety. By supporting these various brain functions, nootropics can help balance our mood, ease anxiety, and improve overall mental well-being.

Now that you understand how nootropics can help restore balance and promote overall mental health, let’s explore 13 different nootropics known to alleviate anxiety and feelings of depression. 

By the way, this is our second article on the topic of anxiety and depression. Check out the first article we published here – Nootropics for Depression.

1. Kava’s calming effect

Kava, a traditional drink from the South Pacific islands, has been cherished for its calming effects and ability to reduce anxiety for centuries. Made from the root of the Piper methysticum plant, kava promotes relaxation without making you feel sedated or affecting your cognitive function. The secret lies in its active compounds, called kavalactones, which interact with brain receptors to modulate neurotransmitters like GABA and dopamine. This helps reduce anxiety, tension, and restlessness, while also boosting a sense of well-being and contentment.

In my personal experience, incorporating kava into my daily routine has been a game-changer. Its calming effects have helped me navigate stressful situations with greater ease and have provided a natural alternative to conventional anxiety medications, which often come with undesirable side effects.

Kava is known for its anti-anxiety and calming effects, improving cognition & memory, and reducing irritability and depression.
With one of the highest concentrations available, Liftmode’s kava extract powder has been vigorously HPLC-tested to confirm its 30% purity, a potency beyond what LiftMode has offered in the past.

We recommend Liftmode’s Kava extract powder with 30% kavalactones which has been vigorously HPLC-tested to confirm its 30% purity. 

Kava extract dosage recommendations

Liftmode recommends starting with a single 500mg serving. You can take 1-2 servings a day, with or without food, as needed. Begin with the lowest dose of 500mg and see how your body responds before considering any adjustments. As with all nootropics, it’s important to start with the lowest possible dose and carefully monitor your response before adjusting your intake.

2. Lion’s Mane Mushroom for mental health

Lion’s Mane Mushroom, also known as Hericium erinaceus, is a nootropic recognized for supporting cognitive function and mental well-being. Used in traditional Chinese medicine for centuries, it contains hericenones, which stimulate the growth and repair of neurons in the brain. This neuroprotective effect can help combat cognitive decline and aid in the regeneration of damaged brain cells, making it a promising natural remedy for anxiety and depression. Additionally, compounds in Lion’s Mane modulate neurotransmitters like serotonin and dopamine, crucial for mood regulation. By promoting a balanced neurotransmitter system, it can help alleviate anxiety and depression, leading to improved mental clarity and emotional stability.

Lion’s Mane Mushroom extract dosage recommendations

Liftmode recommends starting with a single 1000mg serving. You can take 1-2 servings up to 3 times a day. Begin with the lowest dose of 1000mg and see how your body responds before considering any adjustments. As with all nootropics, it’s important to start with the lowest possible dose and carefully monitor your response before adjusting your intake.

Lion's Mane Mushroom promotes nerve growth factor (NGF) production, potentially improving cognitive function, memory, and overall brain health as a nootropic.
Lion’s mane is an important adaptogen (herbs and fungi that help adapt to stress and support healthy performance). Lion’s Mane is rich in nutrients that support the immune system.

3. Magnesium to reduce anxiety and depression

Magnesium, an essential mineral, is pivotal for regulating mood and stress response. Unfortunately, many suffer from magnesium deficiency due to factors like poor diet and stress. Research indicates its profound impact on anxiety and depression by regulating neurotransmitters like serotonin and dopamine, essential for positive mood and emotional balance. Incorporating magnesium-rich foods such as leafy greens, nuts, seeds, and whole grains can help maintain adequate intake. Additionally, high-quality magnesium supplements like magnesium glycinate or magnesium taurate can effectively address deficiencies and support mental well-being.

Magnesium dosage recommendations

Cosmic Nootropic recommends a daily dose of 6–8 tablets. They recommended dividing the daily dose into 2-3 administrations. Take the tablets with meals washed down by a glass of water.

The average length of the treatment course is one month. Once the amount of magnesium stabilizes, it is recommended to discontinue treatment.

As with all nootropics, start with the lowest dose and see how your body responds before considering any adjustments.

Magnesium improves cognition, memory, learning, recall, reduces brain fog, is an antioxidant, helps neuroplasticity, and protects against glutamate-toxicity.
Use the code “GOODBRAINGUIDE” to get 10% Cosmic Nootropics’s Magnesium

 

Use the code "GOODBRAINGUIDE" to get 10% Cosmic Nootropics's Magnesium
Magnesium improves cognition, memory, learning, recall, reduces brain fog, is an antioxidant, helps neuroplasticity, and protects against glutamate-toxicity.

4. Mucuna Pruriens (L-DOPA) and mood

Mucuna Pruriens, also known as the “velvet bean,” is a tropical legume with a rich history in Ayurvedic medicine. Its standout feature is its high L-DOPA content, a precursor to dopamine and norepinephrine—neurotransmitters crucial for mood, motivation, and stress response. By providing a natural source of L-DOPA, Mucuna Pruriens supports healthy neurotransmitter levels, potentially easing symptoms of depression, low motivation, and lack of focus. Moreover, its neuroprotective properties make it a promising remedy for conditions like Parkinson’s disease and other neurodegenerative disorders.

L-DOPA dosage recommendations

According to Nootropics Expert, the suggested dosage of L-DOPA (Mucuna Pruriens extract) is typically 250 – 500 mg taken twice daily. Since most extracts contain 15 – 20% L-DOPA, you might need to adjust your dosage based on your response to the supplement. It’s advisable to cycle the use of L-DOPA, limiting it to 4 or 5 days a week, to prevent tolerances and dependencies, common with dopamine agonists. As with all nootropics, start with the lowest dose and monitor your body’s response before making any adjustments.

L-DOPA (Mucuna Pruriens) is known for improving brain health, is an antioxidant and heavy metal chelator, improves memory & cognitive function, lowers symptoms of depression, and boosts libido.
Science.bio’s L-DOPA is batch and lot coded with publicly visible lab reports to ensure quality and transparency.

5. N-Acetylcysteine Ethyl Ester (NACET)’s impact on anxiety and depression

N-acetyl cysteine ethyl ester (NACET) is a potent antioxidant and precursor to cysteine, essential for producing the antioxidant glutathione. While often used for respiratory issues like bronchitis and COPD, NACET also shows promise in alleviating anxiety and depression. It helps regulate glutamate levels, an excess of which can lead to anxiety and depression, thereby restoring balance in the brain’s neurotransmitter system. Additionally, its anti-inflammatory properties may reduce brain inflammation, further enhancing its mood-boosting effects.

NACET dosage recommendations

Liftmode recommends a single 50mg serving. As with all nootropics, start with the lowest dose and see how your body responds before considering any adjustments. Never take NACET with any nitrates, especially Nitroglycerin. 

N-Acetyl L-Cysteine (NAC) is a powerful anti-oxidant, can boost mood, lower anxiety, improve memory, and reduce compulsive behavior
Liftmode’ N-acetyl cysteine ethyl ester (NACET) is a supplement form of the amino acid cysteine with a greater bioavailability than N-acetyl cysteine (NAC). NACET is a potent scavenger of harmful free radicals.

6. N-Acetyl L-Tyrosine (NALT), a mood enhancer

N-acetyl L-tyrosine (NALT) is a modified form of the amino acid tyrosine, designed for better absorption and bioavailability. As a precursor to neurotransmitters like dopamine, norepinephrine, and epinephrine, NALT supports mood, motivation, and stress response. By providing an easily absorbed source of tyrosine, NALT helps replenish neurotransmitter levels depleted by stress, physical activity, or lack of sleep. Additionally, NALT is known to enhance focus, attention, and mental performance, particularly under stressful conditions.

NALT dosage recommendations

Liftmode recommends starting with a single 500mg serving. You can take 1-2 servings up to 2 times a day. Begin with the lowest dose of 500mg and see how your body responds before considering any adjustments. As with all nootropics, it’s important to start with the lowest possible dose and carefully monitor your response before adjusting your intake.

N-Acetyl L-Tyrosine (NALT) enhances working memory, executive function, creative flow states, stress reduction, better mood, anti-anxiety and lessens symptoms of ADHD
Liftmode recommends a single serving size of 500mg taken 1-2 times a day.

7. Nefiracetam and Aniracetam for anxiety and depression

Both part of the racetam family known for cognitive enhancement, Nefiracetam and Aniracetam offer benefits for anxiety and depression as well. Nefiracetam modulates neurotransmitters like GABA, glutamate, and acetylcholine, promoting balance and reducing anxiety while improving mood stability. Aniracetam enhances the release of dopamine and serotonin, key neurotransmitters for mood regulation, helping to alleviate depression and support a positive outlook. Besides boosting memory, focus, and learning, these nootropics can contribute to overall emotional well-being.

Nefiracetam dosage recommendations

Nefiracetam has been shown to reduce apathy, improve cognition, learning, and long-term memory, reduce anxiety, depression and stress, boost nerve growth factor, and is neuroprotective
Neurohackers use Science.bio’s Nefiracetam to boost learning, cognition and memory.

Nootropics Expert recommends a Nefiracetam dosage of 100 mg to 900 mg per day. Taken in divided doses. One Nefiracetam dose in the morning, and one in the early afternoon. As with all nootropics, it’s important to start with the lowest possible dose and carefully monitor your response before adjusting your intake.

Aniracetam dosage recommendations

Nootropics Expert recommends a Aniracetam dosage of 1,500 mg per day. Taken in two 750 mg doses. One Aniracetam dose in the morning, and one in the early afternoon.As with all nootropics, it’s important to start with the lowest possible dose and carefully monitor your response before adjusting your intake.

Aniracetam has been shown to relieve depression, boost learning & memory, improve verbal fluidity, increase music listening pleasure, and make you more social.
A favorite racetam among the nootropics community Neurohackers use Aniracetam to relieve anxiety, depression, stress, and improve sociability.

8. Noopept for anxiety and depression

Noopept, a synthetic nootropic, is popular for its cognitive-enhancing properties and potential benefits in alleviating anxiety and depression. It modulates neurotransmitters like acetylcholine, dopamine, and serotonin, promoting balance and reducing anxiety while improving mood stability. Additionally, Noopept’s neuroprotective properties may help alleviate symptoms associated with neurological conditions or cognitive impairment.

Noopept dosage recommendations

1. Science.bio Noopept

The recommended dosage for Noopept is 10 to 30mg per day. As with all nootropics, it’s important to start with the lowest possible dose and carefully monitor your response before adjusting your intake.

 

Noopept is known for boosting memory, learning, perception, logical thinking, mood, and improved cognitive function.
Noopept is a potent cognitive enhancer with various benefits for memory, learning, perception, and mood.

 

Noopept is known for boosting memory, learning, perception, logical thinking, mood, and improved cognitive function. Noopept is considered safe within the recommended dosage range of 10 – 30 mg per day.
Noopept is considered safe within the recommended dosage range of 10 – 30 mg per day.

Noopept spray provides a convenient and fast-absorbing nootropic solution designed to enhance cognitive function, memory, and focus.

2. Swisschems Noopept

Noopept powder is a potent nootropic supplement designed to enhance cognitive function, memory, and focus by offering a customizable dosage option.
Swisschems Noopept powder, available in a 10-gram package, offers a convenient option for users who prefer to customize their dosage or incorporate it into their daily routine.
Noopept capsules provide a convenient, pre-measured dosage of a powerful nootropic aimed at enhancing cognitive function, memory, and focus.
Swisschems offers Noopept capsules, each containing 30mg of Noopept.

3. Cosmic Nootropic Noopept

Noopept pills offer a precise and easy-to-take dosage of a potent nootropic that enhances cognitive function, memory, and mental clarity.
Cosmic Nootropic offers Noopept capsules designed to enhance cognitive function and support brain health.

9. Phenylalanine and mood regulation

L-Phenylalanine is an essential amino acid vital for producing neurotransmitters like dopamine, norepinephrine, and epinephrine, which regulate mood, motivation, and emotional well-being. By providing a readily available source of phenylalanine, this nootropic can support healthy neurotransmitter levels, potentially easing depression, boosting motivation, and improving focus. Additionally, phenylalanine is a precursor to tyrosine, another amino acid crucial for neurotransmitter production, enhancing its mood-boosting effects.

L-Phenylalanine dosage recommendations

The suggested dosage for L-Phenylalanine is 500mg, up to 3 times per day. Because L-Phenylalanine is an amino acid, it’s best to take it on an empty stomach, at least an hour before food, to ensure optimal absorption and avoid competition with other amino acids. As with all nootropics, it’s important to start with the lowest possible dose and carefully monitor your response before adjusting your intake.

Phenylalanine enhances working memory, executive function, creative flow states, stress reduction, better mood, anti-anxiety and lessens symptoms of ADHD
L-phenylalanine can be a highly effective nootropic for boosting cognitive function because it boosts norepinephrine and dopamine production. Resulting in increased attention, motivation and working memory.

10. Rhodiola Rosea for anxiety and depression

Rhodiola Rosea, also known as “golden root,” is an adaptogenic herb used in traditional medicine for centuries. This nootropic is notable for alleviating anxiety and depression and enhancing stress resilience. Rhodiola Rosea works by modulating neurotransmitters like serotonin, dopamine, and norepinephrine, promoting balance and improving mood stability. Its neuroprotective properties further contribute to easing anxiety and depression, particularly those linked to neurological conditions or cognitive impairment.

Rhodiola Rosea dosage recommendations

The recommended dosage for Noopept is 150 to 200mg per day. As with all nootropics, it’s important to start with the lowest possible dose and carefully monitor your response before adjusting your intake.

Rhodiola Rosea is known for improving alertness, energy, memory and mood, is anti-anxiety and anti-depressant, reduces fatigue, and boosts cognition and concentration
Rhodiola Rosea is an ancient remedy with remarkable stress-relieving and anti-anxiety properties. And stands shoulder to shoulder with some of the most potent drugs used to treat depression and anxiety.

11. Sulbutiamine to reduce anxiety and depression

Sulbutiamine, a synthetic derivative of vitamin B1 (thiamine), shows promise in relieving symptoms of anxiety and depression. By enhancing thiamine metabolism and utilization in the brain, it boosts energy production and cognitive function. Sulbutiamine modulates neurotransmitters like dopamine, serotonin, and glutamate, promoting balance and improving mood stability. Its neuroprotective properties further support its potential in alleviating symptoms of anxiety and depression linked to neurological conditions or cognitive impairment.

Sulbutiamine dosage recommendations

The recommended Sulbutiamine dosage ranges from 400 mg to 1,000 mg per day, with higher doses split between morning and early afternoon to avoid interference with sleep due to its mild stimulant qualities. As with all nootropics, it’s important to start with the lowest possible dose and carefully monitor your response before adjusting your intake.

Sulbutiamine has been shown to boost motivation, improve focus, enhance memory and alleviate depression
Sulbutiamine helps your body withstand stress. A lack of energy can contribute to poor mood and motivation. Thiamine can boost your mood, and defend against depression and anxiety.

12. Uridine Monophosphate’s (UMP) impact on anxiety and depression

Uridine Monophosphate (UMP), a naturally occurring compound, is essential for various biochemical processes, including synthesizing phospholipids crucial for brain cell membranes. Research suggests UMP positively impacts mental well-being by supporting phospholipid synthesis, enhancing membrane fluidity and brain cell communication, potentially easing anxiety and depression symptoms. Its neuroprotective properties further aid in alleviating symptoms associated with neurological conditions or cognitive impairment.

Uridine Monophosphate (UMP) dosage recommendations

The recommended dosage for Uridine Monophosphate (UMP) is 150 – 250mg taken twice daily. As with all nootropics, it’s important to start with the lowest possible dose and carefully monitor your response before adjusting your intake.

Uridine Monophosphate has been shown to increase neuron and synapse density, dopamine and acetylcholine release, boost learning and memory, and decrease depression
Uridine helps boost the release of dopamine in your brain. Leading to better mood, alertness and cognition.

Conclusion: Harnessing the power of nootropics to manage depression and anxiety 

As you embark on this journey of self-discovery and mental well-being, natural and synthetic nootropics offers a promising solution to effective ways to alleviate symptoms of anxiety and depression while promoting overall cognitive function and emotional balance.

Use the code GOODBRAINGUIDE10 for 10% off all Science.bio and Liftmode.com nootropics. 

*This post contains affiliate links, so we may earn a small commission when you make a purchase through links on our site at no additional cost to you.

 

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